Gliomatosis Cerebri: A Report of Three Cases with Literature Review

Abstract

Gliomatosis cerebri is a rare glioma of poor prognosis due to its diff use infiltration of the central nervous system involving three or more lobes of the brain. It has non-specifi c symptoms such as epilepsy, cognitive
disorders, headache and change in personality. Three cases of gliomatosis cerebri are reported. Extensive literature review was done. This review includes defi nition, type, clinical presentation, diagnosis [radiological and pathological], deferential diagnosis, treatment, and prognosis. In conclusion gliomatosis cerebri was initially a postmortem diagnosis. Following the advancement of the MRI, it became a radiological diagnosis that induces diff use involvement of at least three contiguous lobes of the brain with relative preservation
of its general anatomical confi guration. It is manifested clinically as a very aggressive disease with poor prognosis. Imaging plays an important role in initial diagnosis, biopsy planning and follow up.